Product Name
Noggin (nog), Recombinant Protein
Full Product Name
Recombinant Xenopus laevis Noggin (nog)
Product Gene Name
nog recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
20-222aa, Full Length of Mature Protein
Sequence
RIDQGGCQHY LHIRPAPSEN LPLVDLIEHP DPIYDPKEKD LNETLLRTLM VGHFDPNFMA TILPEERLGV EDLGELDLLL RQKPSGAMPA EIKGLEFYEG LQSKKHRLSK KLRRKLQMWL WSQTFCPVLY TWNDLGTRFW PRYVKVGSCY SKRSCSVPEG MVCKAAKSMH LTILRWRCQR RVQQKCAWIT IQYPVISECK CSC
3D Structure
ModBase 3D Structure for P49011
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Xenopus laevis (African clawed frog)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of nog recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for nog. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001079113.1
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NCBI GenBank Nucleotide #
NM_001085644.1
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UniProt Primary Accession #
P49011
[Other Products]
UniProt Related Accession #
P49011[Other Products]
Molecular Weight
25,799 Da
NCBI Official Full Name
noggin
NCBI Official Synonym Full Names
noggin L homeolog
NCBI Official Symbol
nog.L [Similar Products]
NCBI Official Synonym Symbols
nog; nog1; nog-A; Noggin1; noggin-1
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NCBI Protein Information
noggin
UniProt Protein Name
Noggin
UniProt Gene Name
nog [Similar Products]
UniProt Comments for nog
Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface receptors. Capable of inducing dorsal development in embryos. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with xWNT-8 and nuclear, sequence-specific DNA-binding protein xBRA. None of these molecules causes dorsal mesoderm formation when expressed alone.
Research Articles on nog
1. noggin 1, differently from noggin 2 and noggin 4, is expressed during all phases of Xenopus laevis retinal development. Gain-of-function experiments by electroporation in the optic vesicle show that overexpression of noggin 1 significantly decreases the number of bipolar cells in the inner nuclear layer of the retina, without significantly affecting the generation of the other retinal cell types.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
