Myosin-7, ELISA Kit

Myosin-7; Myosin heavy chain 7; Myosin heavy chain slow isoform; MyHC-slow; Myosin heavy chain, cardiac muscle beta isoform; MyHC-beta; Myh7

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of Myh7 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2886057 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Myosin-7 (Myh7) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Myh7. The ELISA analytical biochemical technique of the MBS2886057 kit is based on Myh7 antibody-Myh7 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Myh7 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Myh7. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

223,083 Da

myosin, heavy chain 7, cardiac muscle, beta

myosin-7

Myosin-7

MyHC-slow; MyHC-beta  [Similar Products]

MYH7_RAT

heavy chain of myosin; involved in muscle contraction [RGD, Feb 2006]

MYH7: Muscle contraction. Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH7 are the cause of myopathy myosin storage (MYOMS). In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM); also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm. Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH7 are the cause of myopathy distal type 1 (MPD1). MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.

Protein type: Motility/polarity/chemotaxis; Motor

Cellular Component: cytoplasm; focal adhesion; muscle myosin complex; myofibril; myosin complex; nucleoplasm; stress fiber; Z disc

Molecular Function: actin binding; actin-dependent ATPase activity; ATP binding; ATPase activity; calmodulin binding; microfilament motor activity; motor activity; protein heterodimerization activity; protein homodimerization activity

Biological Process: ***** heart development; ATP metabolic process; cardiac muscle contraction; cardiac muscle hypertrophy; muscle contraction; muscle filament sliding; regulation of heart rate; regulation of slow-twitch skeletal muscle contraction; regulation of the force of heart contraction; regulation of the force of skeletal muscle contraction; skeletal muscle contraction; striated muscle contraction; transition between fast and slow fiber; ventricular cardiac muscle morphogenesis

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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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