Integral membrane protein 2C (ITM2C), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of ITM2C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7238994 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Integral membrane protein 2C (ITM2C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ITM2C. The ELISA analytical biochemical technique of the MBS7238994 kit is based on ITM2C antibody-ITM2C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ITM2C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ITM2C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Neurobiology

25,921 Da

integral membrane protein 2C

integral membrane protein 2C; cerebral protein 14; transmembrane protein BRI3; integral membrane protein 3; BRICHOS domain containing 2C

Integral membrane protein 2C

BRI3; hucep-14; NPD018; PSEC0047  [Similar Products]

ITM2C_HUMAN

ITM2C: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Belongs to the ITM2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: Golgi apparatus; lysosomal membrane; lysosome; perinuclear region of cytoplasm; plasma membrane; integral to membrane

Molecular Function: protein binding; beta-amyloid binding; ATP binding

Biological Process: neuron differentiation

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