Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), Recombinant Prote

Recombinant Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2); Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2 EC= 3.6.3.8; Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skel

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 26; NC_006608.3 (8148566..8209392). Location: chromosome: 26

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of ATP2A2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

109,653 Da[Similar Products]

sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic reticulum Ca2+-transport ATPase isoform; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

SERCA2  [Similar Products]

AT2A2_CANFA

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle

By similarity.

Catalytic activity: ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Enzyme regulation: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.

Subunit structure: Associated with phospholamban (PLN). Isoform SERCA2B interacts with TRAM2 (via C-terminus). Interacts with HAX1

By similarity. Interacts with S100A8 and S100A9

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity: Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed.

Post-translational modification: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity

By similarity.

Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

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