Product Name
GABA(B) Receptor 1 (GABBR1), Polyclonal Antibody
Full Product Name
GABA(B) Receptor 1 (GBR1)
Product Synonym Names
Anti -GABA(B) Receptor 1 (GBR1)
Product Gene Name
anti-GABBR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (29570005..29600962, complement). Location: 6p21.31
3D Structure
ModBase 3D Structure for Q53EM0
Specificity
Recognizes rat GABA B Receptor 1.
Purity/Purification
Serum
Serum
Form/Format
Supplied as a liquid.
Immunogen
EKENRELEKIIAEKEERVSELRH
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-GABBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-GABBR1 antibody
Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-GABBR1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-GABBR1 antibody
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry: 1:1000-1:3000
NCBI/Uniprot data below describe general gene information for GABBR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_068703.1
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NCBI GenBank Nucleotide #
NM_021903.2
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UniProt Primary Accession #
Q53EM0
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UniProt Related Accession #
Q53EM0; Q59HG8; Q5SUJ9; Q71SG6; Q8IW08; Q8NHA5; Q9UBS5[Other Products]
Molecular Weight
95,134 Da[Similar Products]
NCBI Official Full Name
gamma-aminobutyric acid type B receptor subunit 1 isoform b
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) B receptor, 1
NCBI Official Symbol
GABBR1 [Similar Products]
NCBI Official Synonym Symbols
GB1; GPRC3A; GABABR1; FLJ92613; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2
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NCBI Protein Information
gamma-aminobutyric acid type B receptor subunit 1; GABA-BR1; GABAB, subunit 1c; OTTHUMP00000029114; OTTHUMP00000029115; OTTHUMP00000029116; OTTHUMP00000109099; OTTHUMP00000214725; seven transmembrane helix receptor
UniProt Protein Name
Gamma-aminobutyric acid (GABA) B receptor 1 isoform b variant
Protein Family
Gamma-aminobutyric acid type B receptor
UniProt Entry Name
Q53EM0_HUMAN
NCBI Summary for GABBR1
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq]
Research Articles on GABBR1
1. Data suggest that the GABAB1 intron 4 containing N-terminal truncation is necessary for the inhibitory action of the new splice variants.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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