Full Product Name
GABRR2 Antibody
Product Gene Name
anti-GABRR2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28476
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-GABRR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GABRR2 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GABRR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002034.3
[Other Products]
NCBI GenBank Nucleotide #
NM_002043.4
[Other Products]
UniProt Primary Accession #
P28476
[Other Products]
UniProt Secondary Accession #
Q9H153; A2BDE4[Other Products]
UniProt Related Accession #
P28476[Other Products]
Molecular Weight
56,817 Da
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit rho-2
NCBI Official Synonym Full Names
gamma-aminobutyric acid type A receptor rho2 subunit
NCBI Official Symbol
GABRR2 [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid receptor subunit rho-2
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit rho-2
UniProt Synonym Protein Names
GABA(A) receptor subunit rho-2; GABA(C) receptor
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
GABRR2 [Similar Products]
NCBI Summary for GABRR2
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016]
UniProt Comments for GABRR2
GABRR2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: integral to plasma membrane; plasma membrane
Biological Process: signal transduction; synaptic transmission; transport
Research Articles on GABRR2
1. GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use.
Precautions
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Disclaimer
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