Product Name
FANCL, Blocking Peptide
Full Product Name
FANCL Immunizing Peptide
Product Synonym Names
FANCL; Fanconi anemia, complementation group L; FAAP43; FLJ10335; PHF9; POG; PHD finger protein 9
Product Gene Name
FANCL blocking peptide
[Similar Products]
FANCL peptide (MBS427286) is used for blocking the activity of FANCL antibody (MBS422401)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat, Dog, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of FANCL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FANCL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001108108.1
[Other Products]
NCBI Related Accession #
Manufactured in an ISO 9001:2008 Certified Laboratory.NP_060532.2[Other Products]
NCBI GenBank Nucleotide #
NM_001114636.1
[Other Products]
UniProt Secondary Accession #
Q6GU60[Other Products]
UniProt Related Accession #
Q9NW38[Other Products]
Molecular Weight
43,430 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase FANCL isoform 1
NCBI Official Synonym Full Names
Fanconi anemia complementation group L
NCBI Official Symbol
FANCL [Similar Products]
NCBI Official Synonym Symbols
POG; PHF9; FAAP43
[Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase FANCL
UniProt Protein Name
E3 ubiquitin-protein ligase FANCL
UniProt Synonym Protein Names
Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
FANCL [Similar Products]
UniProt Synonym Gene Names
PHF9; FAAP43 [Similar Products]
UniProt Entry Name
FANCL_HUMAN
NCBI Summary for FANCL
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for FANCL
FANCL: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Defects in FANCL are the cause of Fanconi anemia complementation group L (FANCL). FANCL is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: cytoplasm; nuclear envelope; nucleoplasm
Molecular Function: ligase activity; metal ion binding; protein binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity
Biological Process: DNA repair; gamete generation; positive regulation of defense response to virus by host; protein monoubiquitination; regulation of cell proliferation; response to DNA damage stimulus
Disease: Fanconi Anemia, Complementation Group L; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Research Articles on FANCL
1. Loss-of-Function FANCL Mutations Associate with Severe Fanconi Anemia Overlapping the VACTERL Association
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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