10 kDa heat shock protein, Recombinant Protein

10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Greater than 90% as determined by SDS-PAGE. (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of HSPE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

Neuroscience

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

14.9kD

heat shock protein family E (Hsp10) member 1

10 kDa heat shock protein, mitochondrial

10 kDa heat shock protein, mitochondrial

Hsp10; CPN10; EPF  [Similar Products]

CH10_HUMAN

This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

HSPE1: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. Belongs to the GroES chaperonin family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; chaperone binding; protein binding; unfolded protein binding

Biological Process: caspase activation; osteoblast differentiation; protein folding; response to unfolded protein

Identification and cloning of human chaperonin 10 homologue.Monzini N., Legname G., Marcucci F., Gromo G., Modena D.Biochim. Biophys. Acta 1218:478-480(1994)

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