ECGF1, Polyclonal Antibody

Anti -ECGF1, ID (Thymidine Phosphorylase, TdRPase, TP, Platelet-derived Endothelial Cell Growth Factor, PD-ECGF, Gliostatin, TYMP)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 22; NC_000022.10 (50964181..50968514, complement). Location: 22q13.33

Polyclonal

IgG

Rabbit

Recognizes human ECGF1.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-TYMP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ECGF1 is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in the gene encoding ECGF1 have been associated with mitochondrial neurogastrointestinal encephalomyopathy.

Antibodies; Abs to Enzymes, Phosphorylase

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

49,955 Da[Similar Products]

thymidine phosphorylase

thymidine phosphorylase; tdRPase; gliostatin

Thymidine phosphorylase

ECGF1; TP; PD-ECGF  [Similar Products]

TYPH_HUMAN

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Protein type: Cytokine; DNA replication; Transferase; Nucleotide Metabolism - pyrimidine; EC 2.4.2.4; Motility/polarity/chemotaxis; Xenobiotic Metabolism - drug metabolism - other enzymes; Phosphorylase

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: cytosol

Molecular Function: thymidine phosphorylase activity; growth factor activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity; platelet-derived growth factor receptor binding

Biological Process: mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside salvage; angiogenesis; chemotaxis; DNA replication; cell differentiation

Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type)

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