Full Product Name
PIGW Polyclonal Antibody
Product Synonym Names
Phosphatidylinositol-glycan biosynthesis class W protein; PIG-W; EC 2.3.-.-; PIGW
Product Gene Name
anti-PIGW antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q7Z7B1
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 370-450
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-PIGW antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PIGW antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PIGW antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for PIGW. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001333683.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001346754.1
[Other Products]
UniProt Primary Accession #
Q7Z7B1
[Other Products]
UniProt Secondary Accession #
Q8N9G3[Other Products]
UniProt Related Accession #
Q7Z7B1[Other Products]
NCBI Official Full Name
phosphatidylinositol-glycan biosynthesis class W protein
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis class W
NCBI Official Symbol
PIGW [Similar Products]
NCBI Official Synonym Symbols
Gwt1; HPMRS5
[Similar Products]
NCBI Protein Information
phosphatidylinositol-glycan biosynthesis class W protein
UniProt Protein Name
Phosphatidylinositol-glycan biosynthesis class W protein
Protein Family
Phosphatidylinositol-glycan biosynthesis class W protein
UniProt Gene Name
PIGW [Similar Products]
UniProt Synonym Gene Names
PIG-W [Similar Products]
NCBI Summary for PIGW
The protein encoded by this gene is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. This occurs in the endoplasmic reticulum and is a step in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors many cell surface proteins to the membrane. Defects in this gene are a cause of the age-dependent epileptic encephalopathy West syndrome as well as a syndrome exhibiting hyperphosphatasia and cognitive disability (HPMRS5). [provided by RefSeq, Jul 2017]
UniProt Comments for PIGW
Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins ().
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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