MCCC1, Polyclonal Antibody

MCCA; MCC-B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody detects endogenous levels of total MCCC1 protein.

Antigen affinity purification

pH 7.4 PBS, 0.05% NaN3, 40% Glycerol

0.8 mg/mL (lot specific)

Store at -20 degree C.

Small volumes of anti-MCCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-2000
IHC: 1:40-200

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 293T, HepG2, A172 cell, Mouse heart tissue, Jurkat cell lysates, Primary antibody:47317(MCCC1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds

The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 47317(MCCC1 Antibody) at dilution 1/45.(Original magnification: 200)

80 kDa

methylcrotonoyl-CoA carboxylase 1

methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

MCCA; MCCase subunit alpha  [Similar Products]

This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.

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