14-3-3 protein sigma (SFN), Polyclonal Antibody

YWHAS; HME1; 14-3-3 Protein Sigma; Epithelial cell marker protein 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>=90% by SDS-PAGE

Lyophilized or Liquid

1 mg/mL (lot specific)

Small volumes of anti-SFN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SDS-PAGE; Western Blot (WB); ELISA (EIA)

24,336 Da

stratifin

14-3-3 protein sigma

14-3-3 protein sigma

HME1  [Similar Products]

14-3-3 sigma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. Homodimer. Interacts with KRT17 and SAMSN1. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. Belongs to the 14-3-3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: cell-cell adherens junction; cytoplasm; cytoplasmic vesicle membrane; cytosol; extracellular space

Molecular Function: identical protein binding; protein binding; protein kinase C inhibitor activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of caspase activity; negative regulation of protein kinase activity; positive regulation of epidermal cell differentiation; regulation of epidermal cell division; release of cytochrome c from mitochondria; signal transduction

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