Product Name
Low-density lipoprotein receptor-related protein 5 (LRP5), Protein
Full Product Name
Low-density lipoprotein receptor-related protein 5
Product Synonym Names
Lrp7; Low-density lipoprotein receptor-related protein 7; Lr3; LRP-7
Product Gene Name
LRP5 protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1407-1614aa
3D Structure
ModBase 3D Structure for Q91VN0
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of LRP5 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for LRP5 protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for LRP5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032539.2
[Other Products]
NCBI GenBank Nucleotide #
NM_008513.3
[Other Products]
UniProt Primary Accession #
Q91VN0
[Other Products]
UniProt Secondary Accession #
O88883; Q9R208; E9QQ75[Other Products]
UniProt Related Accession #
Q91VN0[Other Products]
Molecular Weight
178,885 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 5
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein 5
NCBI Official Symbol
Lrp5 [Similar Products]
NCBI Official Synonym Symbols
HBM; LR3; LRP7; OPPG; BMND1; mKIAA4142
[Similar Products]
NCBI Protein Information
low-density lipoprotein receptor-related protein 5
UniProt Protein Name
Low-density lipoprotein receptor-related protein 5
UniProt Synonym Protein Names
Low-density lipoprotein receptor-related protein 7; LRP-7; Lr3
Protein Family
Low-density lipoprotein receptor-related protein
UniProt Gene Name
Lrp5 [Similar Products]
UniProt Synonym Gene Names
Lrp7; LRP-5; LRP-7 [Similar Products]
UniProt Comments for LRP5
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (). Appears be required for postnatal control of vascular regression in the eye (PubMed:11956231). Required for posterior patterning of the epiblast during gastrulation (PubMed:15142971).
Research Articles on LRP5
1. Megakaryocytes are increased in the bone marrow of Lrp5G170V/G170V mice. Depletion of megakaryocytes does not affect the Lrp5-induced high bone mass.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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