TUBB2B, Monoclonal Antibody

Anti-TUBB2B Antibody (clone AT5B3) IHC-plus; TUBB2B; BA506K6.1; Class IIb beta-tubulin; PMGYSA; RP11-506K6.1; Tubulin; beta 2B; Class II beta-tubulin isotype; Tubulin beta-2B chain; Tubulin; beta 2B class IIb; Human TUBB2B

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

Ig2a,k

AT5B3

Mouse

Protein G Purified

Phosphate buffered saline, pH 7.4, 0.1% sodium azide

1 mg/ml (lot specific)

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Small volumes of anti-TUBB2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin)

IHC-P (5 ug/ml)

Anti-TUBB2B antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Anti-TUBB2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

49,953 Da

tubulin, beta 2B class IIb

tubulin beta-2B chain; class IIb beta-tubulin; class II beta-tubulin isotype; tubulin, beta polypeptide paralog

Tubulin beta-2B chain

TBB2B_HUMAN

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

TUBB2B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2B is implicated in neuronal migration. Defects in TUBB2B are a cause of polymicrogyria asymmetric (PMGA). PMGA is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: microtubule; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; neuron migration; transmembrane transport; microtubule-based process

Disease: Polymicrogyria, Symmetric Or Asymmetric

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