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产品名称: Recombinant Rat IL13
产品型号: Z300095
产品展商: 其他品牌
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简单介绍
Recombinant Rat IL13
Recombinant Rat IL13
的详细介绍
|
Print Version |
| Alternative Names |
IL-13, T-cell activation protein P600
Recombinant Rat Interleukin-13 (IL13) |
| Description |
Mouse IL-13 is produced primarily by activated Th2 cells. Human IL-13 is expressed in activated T helper cells (resembling Th0, Th1, Th2), and T cells expressing CD8. The alpha chain of the IL-13 receptor has weak binding activity for IL-13. High affinity receptors are formed when the receptor alpha chains of IL-13 and IL-4 receptors are coexpressed. The receptors for IL-3 and IL-4 share a component, a common gamma subunit that is found also in the IL-2 receptor. Different IL-13 receptor structures have been shown to exist on various cell types and the IL-13 receptor may share more than one component with IL-4 receptor. IL-13 down-modulates macrophage activity, reducing the production of pro-inflammatory cytokines and chemokines in response to IFN-gamma or bacterial lypopolysaccharides. IL-13 enhances the production of the IL1 receptor antagonist IL-1ra. IL-13 also decreases the production of nitric oxide by activated macrophages, leading to a decrease in parasiticidal activity. IL-13 induces differentiation of human monocytes, enhances survival time in culture, and also induces differentiation and proliferation and isotype switching in B-cells. |
| Gene Symbol |
IL13 |
| Gene ID |
116553 |
| Accession No. |
P42203 |
| Source |
E. coli |
| Appearance |
Lyophilized Powder |
| Molecular Weight |
12.0 kDa |
| Endotoxin Level |
<1.0 EU/μg of recombinant protein as determined by the LAL method. |
| Purity |
>95% as determined by SDS-PAGE |
| Bioactivity |
The ED(50) was determined by the dose-dependent proliferation of TF-1 cells was ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 1.0 x 10^6 units/mg. |
| Formulation |
Recombinant Rat IL-13 was lyophilized from a 0.2 μm filtered PBS solution. |
| Reconstitution |
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage |
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage |
For research use only. Not for diagnostic or therapeutic use. |
