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产品名称: KLF4 Purified Protein
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简单介绍
KLF4 Purified Protein
KLF4 Purified Protein
的详细介绍
|
Print Version |
| Organism |
Human |
| Accession # |
O43474 |
| Alias |
EZF, GKLF |
| Protein Type |
Wild Type |
| Protein Sequence |
HHHHHHRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHFESGGGGSPGRRRRRRRRR |
| Protein Family |
Belongs to the krueppel C2H2-type zinc-finger protein family. |
| Functions |
Transcription factor which acts as both an activator and repressor. KLF4 binds the CACCC core sequence. It also binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. KLF4 is required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface.
KLF4 is one of the four factors in the Yamanaka protocol for iPSC reprogramming. The purified recombinant protein has a 6X His tag at N-terminus for purification and 9X poly-arginine at C-terminus for cell membrane penetration. |
| Cell Types |
Unknown |
| Protein Location |
Nucleus |
| Tag |
6X His tag at N-terminus and 9X Poly-Arginine at C-terminus |
| Form |
Liquid |
| Expression System |
E.coli |
| Type |
Purified Protein |
| Purification |
Affinity Chromatography |
| Quality Control |
By Western Blot Analysis |
| Concentration |
250ug/ml |
| Storage |
PBS |
| Shipping |
On dry ice. |
| Notes |
For Research Use Only, not for therapeutic or diagnostic purposes. |
| References |
Induction of pluripotent stem cells from ***** human fibroblasts by defined factors. Takahashi et al. Cell. 2007 Nov 30;131(5):861-72.
Induction of pluripotent stem cells from mouse embryonic and ***** fibroblast cultures by defined factors. Takahaski and Yamanaka. Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10. |
