APC - anti mouse CD357 - Clone DTA-1
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产品名称: APC - anti mouse CD357 - Clone DTA-1
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APC - anti mouse CD357 - Clone DTA-1
APC - anti mouse CD357 - Clone DTA-1
的详细介绍
APC
- anti Mouse
CD357 - DTA-1
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The minimum purchase order quantity for the product is 1
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DTA-1
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Rat IgG2b
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Flow Cytometry
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APC
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0.2 mg/ml
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Mouse CD25+ CD4+ T Cell Line
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Mouse
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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Liquid
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Store in the dark at 2-8 °C
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CD357 (GITR; glucocorticoid-induced TNFR-related gene) is a member of the TNF receptor superfamily, also known as TNFRSF18 and AITR (in humans). It is expressed at low levels on resting T lymph ocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-?B activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
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Glucocorticoid-induced TNFR -related gene, TNFRSF18
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70 kD
