Catalogue number
PRO-2263
Synonyms
Lysosomal-Associated
Membrane Protein 3, DC-Lysosome-Associated Membrane Glycoprotein, DC LAMP,
LAMP-3, DCLAMP, TSC403, Protein TSC403, CD208 Antigen, DC-LAMP, CD208, LAMP, Lysosome-associated
membrane glycoprotein 3.
Introduction
Lysosomal-Associated Membrane Protein 3, also known as LAMP3 is part of
the lysosome-associated membrane protein family. LAMP3 and CD68 share an
extremely similar predicted structure. LAMP3 performs in dendritic cell
function and in adaptive immunity as well.
Furthermore, LAMP3 overexpression is actively involved in tumor invasion via increased migration into lymph-vascular spaces.
Description
LAMP3 produced in Sf9 Baculovirus cells is a single,
glycosylated polypeptide chain containing 362 amino acids (28-381a.a.) and
having a molecular mass of 38.8kDa.
(Molecular size on SDS-PAGE will appear at
approximately 57-70kDa).
LAMP3 is expressed with an
8 amino acid His tag at C-Terminus and purified by proprietary chromatographic
techniques.
Source
Sf9,
Baculovirus cells.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
LAMP3 protein solution (0.5mg/ml) contains Phosphate
Buffered Saline (pH 7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
KAFPETRDYS QPTAAATVQD IKKPVQQPAK QAPHQTLAAR FMDGHITFQT
AATVKIPTTT PATTKNTATT SPITYTLVTT QATPNNSHTA PPVTEVTVGP SLAPYSLPPT ITPPAHTTGT
SSSTVSHTTG NTTQPSNQTT LPATLSIALH KSTTGQKPVQ PTHAPGTTAA AHNTTRTAAP
ASTVPGPTLA PQPSSVKTGI YQVLNGSRLC IKAEMGIQLI VQDKESVFSP
RRYFNIDPNA TQASGNCGTR KSNLLLNFQG GFVNLTFTKD EESYYISEVG AYLTVSDPET IYQGIKHAVV
MFQTAVGHSF KCVSEQSLQL SAHLQVKTTD VQLQAFDFED DHFGNVDECS SDYTLEHHHH
HH.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
