Catalogue number
PRO-2254
Synonyms
Adhesion
Molecule with Ig-Like Domain 2, Differentially Expressed in Gastric, Adenocarcinomas,
AMIGO-2, ALI1, DEGA, Differentially Expressed in Gastric, Adenocarcinoma, Amphoterin-Induced
Gene and Open Reading Frame 2, Transmembrane Protein AMIGO2, Amphoterin Induced
Gene, Alivin 1, Alivin-1.
Introduction
Adhesion Molecule with Ig-Like Domain 2, also known as AMIGO2 is a member
of the leucine-rich repeat family. AMIGO2 arbitrates homophilic in addition to
heterophilic cell-cell interaction with AMIGO1 or AMIGO3. Furthermore, AMIGO2 contributes to signal transduction via its intracellular domain and is
also essential for tumorigenesis of a subset of gastric adenocarcinomas.
Description
AMIGO2 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 367 amino acids (40-398a.a.) and having a molecular mass of 41.9kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
AMIGO2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9,
Insect cells.
Physical Appearance
Sterile
filtered colorless solution.
Formulation
AMIGO2
protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%
glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 95.0% as determined by SDS-PAGE.
Amino acid sequence
VCPTACICAT DIVSCTNKNL SKVPGNLFRL IKRLDLSYNR IGLLDSEWIP VSFAKLNTLI
LRHNNITSIS TGSFSTTPNL KCLDLSSNKL KTVKNAVFQE LKVLEVLLLY NNHISYLDPS AFGGLSQLQK LYLSGNFLTQ FPMDLYVGRF KLAELMFLDV SYNRIPSMPM HHINLVPGKQ LRGIYLHGNP FVCDCSLYSL LVFWYRRHFS SVMDFKNDYT CRLWSDSRHS RQVLLLQDSF MNCSDSIING SFRALGFIHE AQVGERLMVH CDSKTGNANT DFIWVGPDNR LLEPDKEMEN FYVFHNGSLV IESPRFEDAG VYSCIAMNKQ RLLNETVDVT INVSNFTVSR SHAHEAFNTL EHHHHHH.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
