Catalogue number
PRO-2198
Synonyms
Serpin B3, Squamous cell carcinoma antigen 1, Protein
T4-A, SCCA-1, Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3,
SCCA1, Serine (Or Cysteine) Proteinase Inhibitor, Clade B
(Ovalbumin), Member 3, Squamous Cell Carcinoma Antigen 1, Protein T4-A, SCCA-1,
Serpin B3, HsT1196, SCCA-PD, T4-A , SCCA, SCC.
Introduction
Serpin
Peptidase Inhibitor, Clade B Member 3, also known as SERPINB3 is a papain-like
cysteine protease inhibitor which modulates the host immune response versus tumor
cells. SERPINB3 is a protein coding gene which acts as an inhibitor of UV-induced
apoptosis by suppressing the activity of c-Jun NH(2)-terminal kinase (JNK1).
Description
SERPINB3 Human Recombinant produced in E.Coli is a
single, non-glycosylated polypeptide chain containing 413 amino acids (1-390 a.a)
and having a molecular mass of 47kDa.
SERPINB3 is fused to a 23 amino acid His-tag at
N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
SERPINB3 protein solution (0.5mg/ml) containing Phosphate
buffered saline (pH7.4),
10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMNSLSEA NTKFMFDLFQ QFRKSKENNI FYSPISITSA LGMVLLGAKD
NTAQQIKKVL HFDQVTENTT GKAATYHVDR SGNVHHQFQK LLTEFNKSTD AYELKIANKL FGEKTYLFLQ
EYLDAIKKFY QTSVESVDFA NAPEESRKKI NSWVESQTNE KIKNLIPEGN IGSNTTLVLV NAIYFKGQWE
KKFNKEDTKE EKFWPNKNTY KSIQMMRQYT SFHFASLEDV QAKVLEIPYK GKDLSMIVLL PNEIDGLQKL
EEKLTAEKLM EWTSLQNMRE TRVDLHLPRF KVEESYDLKD TLRTMGMVDI FNGDADLSGM TGSRGLVLSG
VLHKAFVEVT EEGAEAAAAT AVVGFGSSPT STNEEFHCNH PFLFFIRQNK TNSILFYGRF SSP.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
