ATTO488-ProTx-I
ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a)
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产品名称: ATTO488-ProTx-I
ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a)
产品型号: PTF003
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
ATTO488-ProTx-I
ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a)
的详细介绍
ATTO488-ProTx-I
ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a) is a fluorescently labeled ProTx-I that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2. ProTx-I is also an antagonist of TRAP1.
