Biotin-ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
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产品名称: Biotin-ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
产品型号: PTB001-00100
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
Biotin-ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
的详细介绍
Biotin-ProTx-I
Blocker of voltage-gated sodium channels and T-type Cav
Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. Biotin-ProTx-I is a biotin-tagged version of ProTx-I.
