ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
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产品名称: ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
产品型号: ADT001-00010
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
的详细介绍
ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.
