ω-agatoxin-IVA
Blocker of P/Q-type calcium channel (Cav2.1)
如果您对该产品感兴趣的话,可以
产品名称: ω-agatoxin-IVA
Blocker of P/Q-type calcium channel (Cav2.1)
产品型号: 11AGA001-00100
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
ω-agatoxin-IVA
Blocker of P/Q-type calcium channel (Cav2.1)
的详细介绍
ω-agatoxin-IVA
Blocker of P/Q-type calcium channel (Cav2.1)
ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
