µ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
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产品名称: µ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
产品型号: CON021-00100
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
µ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
的详细介绍
µ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
µ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consors. µ-conotoxin CnIIIC exhibits a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). µ-conotoxin CnIIIC also blocks Nav1.2 channels (1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes. µ-conotoxin CnIIIC completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM).
