产品资料

(Dap22)-ShK (Dap22)-ShK is a highly selective Kv1.3 blocker

如果您对该产品感兴趣的话,可以
产品名称: (Dap22)-ShK (Dap22)-ShK is a highly selective Kv1.3 blocker
产品型号: 13SHD001-00010
产品展商: 其他品牌
产品文档: 无相关文档

简单介绍


(Dap22)-ShK (Dap22)-ShK is a highly selective Kv1.3 blocker  的详细介绍
(Dap22)-ShK (Dap22)-ShK is a highly selective Kv1.3 blocker (Dap22)-ShK (ShK Dap22) peptide is a synthetic derivative of the well-known ShK toxin #08SHK001 (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6 (KCNA6) respectively with a Kd of 11 pM,16 pM, 312 pM and 165 pM. In (Dap22)-ShK, lysine22 has been replaced by a diaminopropionic acid (Dap) residue that greatly improves the selectivity of the peptide for the voltage-gated potassium channel Kv1.3 (IC50 around 23 pM) against Kv1.1 (1.8 nM), Kv1.4 (37 nM) and Kv1.6 (10 nM) channels. The high selectivity of (Dap22)-Shk is achieved thanks to the strong binding between the Dap and His404 / Asp386 residues of Kv1.3 channel. (Dap22)-ShK inhibits T cell proliferation induced by anti-CD3 at subnanomolar concentrations.
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关产品
GsAF-2 Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7 12GSF002-00100
Hainantoxin-III Selective blocker of TTX-S VGSC 13HTX003-00100
Hainantoxin-IV Potent blocker of voltage-gated sodium channels 12HTX001-00100
Tertiapin Q Blocker of Kir Channels 08TER001-00100
TAMRA-Charybdotoxin KCa2+ channel blocker
Tamapin Selective blocker of SK2 (KCa2.2) channels 10TAM001-00100
GsMTx4 Selective blocker of mechanosensitive ion channels 08GSM001-00050
NMB-1 NMB001-00100
MT7 – Muscarinic Toxin 7 Blocker of M1-subtype of muscarinic receptor MTX007-00100
Rho-Conotoxin-TIA Blocker of α1-adrenoreceptor CON022-00100
μ-conotoxin-PIIIA Blocker of Nav1.4 channels 08CON006-00100
8xHis-ProTx-II 8xHis-ProTx-II, Nav1.7 selective blocker PTH002-00100
ATTO488-ProTx-I ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a) PTF003
ATTO488-ProTx-II PTF004
Biotin-ProTx-I Blocker of voltage-gated sodium channels and T-type Cav PTB001-00100
Cy5-Huwentoxin-IV TTX-S selective blocker HWF002-00100
Cy5-ProTx-I Cy5-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a) PTF001
Cy5-ProTx-II Fluorescent Nav1.7 blocker
GrTx1 GrTx1 toxin GRX
GsAF-1 GsAF-1 blocks voltage-gated sodium channels 12GSF001-00100
ρ-Da1a – AdTx1 Selective antagonist of the alpha(1A)-adrenoceptor ADT001-00010
Echistatin α1 isoform ECH001
Obtustatin Inhibitor of the binding of α1β1 integrin to collagen IV 10OBT001-00100
Purotoxin-1 Selective inhibitor of P2X3 receptors 011PUR001-00100
Conantokin-G Selective inhibitor of NR2B-containing NMDAR 08CON009-00500
Crotamine Cell-penetrating peptide and ion channels blocker CRO001
Cy3-Crotamine Fluorescent tumor-cell specific agent CRO002
Lys-conopressin-G Vasopressin-like peptide 11CON014-00500
Melittin Highly pure synthetic Melittin MEL01
Morphiceptin Agonist of µ-opoid receptor 11CAS001-01000
Stromatoxin-1 Blocker of Kv2 channels SCT01-00100
ShK – Stichodactyla toxin Selective blocker of Kv1.3
Phrixotoxin-2 Phrixotoxin-2, a blocker of Kv4.2 and Kv4.3 channels
Maurotoxin Maurotoxin Kv and SK channels blocker 08MAR001-00100
TMR-ShK Fluorescent (red) Kv1.3 blocker SAT001-00100
Huwentoxin-XVI Huwentoxin-XVI is a selective blocker of N-type Ca2+ channels
Maurocalcine Maurocalcine, a potent agonist of ryanodine receptors 07MAU001-00100
SNX482 Selective blocker of Cav2.3 channel 08SNX001-00050
ω-agatoxin-IVA Blocker of P/Q-type calcium channel (Cav2.1) 11AGA001-00100
ω-Conotoxin-GVIA Conotoxin GVIA, a selective blocker of Cav2.2 channel 08CON003-00100
ω-Conotoxin-MVIIA ω Conotoxin MVIIA, a potent blocker of Cav2.2 08CON001-00100
ω-Conotoxin-MVIIC Blocker of P/Q and N-type Ca2+ channels 08CON002-00100
ω-Conotoxin-SO3 Selective blocker of N-type calcium channels 08CON013-00100
Chlorotoxin Selective blocker of small conductance chloride channels 08CHL001-00100
GaTx2 Selective blocker of ClC2 (CLCN2) chloride channels 10GTX002-00100
alpha-cobratoxin α7 nicotinic acetylcholine receptor (nAChR) antagonist CBT001
Waglerin-1 Waglerin-1 blocks muscle-type nAChRs 12WAG001-01000
Waglerin-1-FAM Waglerin-1 blocks muscle nAChRs WAG002-01000
α-Conotoxin BuIA CON024-00100
α-Conotoxin PIA CON023

沪公网安备 31011202007343号