Apamin
Apamin is a SK channel blocker
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产品名称: Apamin
Apamin is a SK channel blocker
产品型号: 08APA001-00500
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
Apamin
Apamin is a SK channel blocker
的详细介绍
Apamin
Apamin is a SK channel blocker
Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. Apamin inhibits three subtypes of SK channels (KCa2.1, KCa2.2, and KCa2.3) with different affinity. Apamin does not affect KCa3.1 channel activity. Apamin most likely acts as a pore blocker such as Scyllatoxin or Tamapin, although residues both inside and outside of the pore region of the SK channels participate in apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.
