The Rat/Mouse PINP EIA assay is a specific method to determine PINP released during rat and mouse bone collagen synthesis, and it has no cross-reactivity for human PINP.
The Rat/Mouse PINP EIA assay can be used for determining the bone formation rate from rat and mouse serum samples1, 2, 3, and from the culture medium in rat and mouse osteoblast cultures.
Previous studies have demonstrated that PINP secretion is increased after stimulation of mouse osteoblasts by BMP-4 and oestrogen in vitro. PINP values are also elevated after treatment with PTH in both young ovariectomised rats and old intact rats.