| Overview |
Print Version
|
| Product Name |
Anti-Nerve Growth Factor (p75) Receptor (ME20.4) Antibody |
| Description |
The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds
nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying
specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to
modulate the susceptibility of selective cellular populations to programmed cell death. |
| Subtype |
monoclonal |
| Application |
IHC,ICC/IF,Flow Cyt,other |
| Raised In |
mouse |
| Specificity |
This antibody recognizes the p75NTR (low affinity neurotrophin receptor) in human, primate, rabbit, sheep, dog, cat,
and pig. It was derived from immunization of mice with WM245 melanoma cells. The antibody is routinely tested
by flow cytometry. |
| Immunogen |
WM245 melanoma cells |
| Guarantee |
abm guarantees that all our Anti-Nerve Growth Factor (p75) Receptor (ME20.4) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Properties |
|
| Formulation |
Liquid |
| Quantity |
100 μg |
| Clone |
Monoclonal |
| Storage |
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Storage Buffer |
PBS, pH 7.4 with 0.05% sodium azide. |
| Concentration |
1µg/ul |
| Purity |
Affinity purified |
| Isotype |
IgG1
|
| Species Reactivity |
human,sheep,other |
| Anti-Nerve Growth Factor (p75) Receptor (ME20.4) Antibody Images |
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| Specific References |
|
Y052633 has been referenced in 1 publication.
-
1. Tremere LA, Pinaud R, Grosche J, Hartig W,
Rasmusson DD (2000) Antibody for human p75
LNTR identifies cholinergic basal forebrain of
non-primate species. Neuroreport 11(10):2177-2183.
2. Caneva L, Soligo D, Cattoretti G, De Harven E,
Deliliers GL. (1995) Immuno-electron microscopy
characterization of human bone marrow stromal cells
with anti-NGFR antibodies. Blood Cells Mol Dis
21:73-85.
3. Loy R, Heyer D, Clagett-Dame M, DiStefano PS
(1990) Localization of NGF receptors in normal and
Alzheimer's basal forebrain with monoclonal antibodies
against the truncated form of the receptor. J Neurosci
Res 27:651-664.
4. Ross AH, Grob P, Bothwell M, Elder DE, Ernst CS,
Marano N, Ghrist BFD, Slemp CC, Herlyn M,
Atkinson B, Koprowski H (1984) Characterization of
nerve growth factor receptor in neural crest tumors
using monoclonal antibodies. Proc Natl Acad Sci
USA 81:6681-6685.
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