Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody
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产品名称: Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody
产品型号: Y052138
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简单介绍
Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody
Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody
的详细介绍
| Overview |
Print Version
|
| Product Name |
Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody |
| Description |
EGFR is a transmembrane
glycoprotein that is a member of a family of protein
tyrosine kinases crucial to maintaining a normal
balance in cell growth and development. Growth
factor receptors are involved not only in promoting the
proliferation of normal cells but also in the aberrant
growth of many types of human tumors. For example,
the epidermal growth factor receptor (EGFR) is
mutated and/or over-expressed in many common solid
human squamous cell carcinomas including breast,
brain, bladder, lung, gastric, head & neck, esophagus,
cervix, vulva, ovary, and endometrium. Overexpression
of the EGFR gene occurs in carcinomas
with and without gene amplification. EGFR and ErbB-2
are particularly important in breast cancer because
increased production or activation has been
associated with poor prognosis. EGFR belongs to a
family of growth factor receptors, which also includes
ErbB-2/HER-2/neu, ErbB-3/HER-3/neu and ErbB-
4/HER-4/neu. EGFR can heterodimerize with each of
the members of this family. |
| Subtype |
polyclonal |
| Application |
WB, IP, ELISA |
| Raised In |
rabbit |
| Specificity |
This antiserum is directed against human epidermal growth factor receptor (EGFR) and is useful in
determining its presence in western blotting and immunoprecipitation experiments. This antibody can detect EGFR from human,
mouse and rat sources. Reactivity of this antibody with EGFR from other species is unknown. |
| Immunogen |
This whole rabbit serum was prepared by repeated immunizations with a peptide synthesized using conventional
technology. The sequence of the epitope maps to a region near the carboxy terminus which is identical in human, mouse and rat
EGFR. |
| Guarantee |
abm guarantees that all our Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Properties |
|
| Formulation |
Liquid |
| Quantity |
100 μl |
| Clone |
Polyclonal |
| Storage |
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Storage Buffer |
PBS, pH 7.4 with 0.05% sodium azide. |
| Concentration |
1µg/ul |
| Purity |
Purified |
| Isotype |
IgG |
| Species Reactivity |
human, mouse, rat |
| Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody Images |
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| Specific References |
|
Y052138 has been referenced in 1 publication.
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Sartor, C.I., et al. (1997) The Role of EGF Receptor and STAT-3 Activation in Autonomous Proliferation of SUM-102PT Human Breast Cancer
Cells. Cancer Research 57:978.
Scambia, G., et al. (1993) Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues: Correlation with histopathological
features and receptors for estrogen, progesterone, and the epidermal growth factor. Am. J. Obstet. Gynecol. 168:71-78.
Henzen-Logmans, S.C., et al. (1993) Occurrence of epidermal growth factor receeptors in benign and malignant ovarian tumors and normal
ovarian tissues: an immunohistochemical study. J. Can. Res. Clin. Oncol. 188:303-307.
Sibilia, M., et al. (2000). The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development. Cell
102:211-220.
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