Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody
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产品名称: Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody
产品型号: abx001587
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简单介绍
Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody
Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody
的详细介绍
APBB1 Antibody is a Rabbit Polyclonal antibody against APBB1. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Target |
APBB1 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IHC, IF/ICC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human APBB1. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 49 kDa/52 kDa/53 kDa/54 kDa/76 kDa/77 kDa
Observed MW: 63 kDa |
| Swiss Prot |
O00213
|
| GeneID |
322
|
| Gene Symbol |
APBB1 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
