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产品名称: c-Jun (pS73) Antibody
产品型号: abx000132
产品展商: 其他品牌
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简单介绍
c-Jun (pS73) Antibody
的详细介绍
c-Jun (pS73) Antibody is a Rabbit Polyclonal antibody against c-Jun (pS73). c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regeneration (5) and T cell development (6). AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context (7-9). Other target genes regulate survival as well as hypoxia and angiogenesis (8,10). c-Jun has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis (11,12).
Target |
c-Jun (pS73) |
Reactivity |
Human, Mouse |
Host |
Rabbit |
Clonality |
Polyclonal |
Tested Applications |
WB, IF/ICC |
Recommended dilutions |
WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
Immunogen |
Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Ser73 of human c-Jun. |
Purification |
Affinity purified. |
Form |
Liquid |
Isotype |
IgG |
Conjugation |
Unconjugated |
Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
Molecular Weight |
Calculated MW: 35 kDa Observed MW: 44 kDa |
Swiss Prot |
P05412
|
GeneID |
3725
|
Gene Symbol |
JUN |
Concentration |
> 1 mg/ml |
Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
UNSPSC Code |
12352203 |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |