APC - anti human CD123 - Clone AC145
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产品名称: APC - anti human CD123 - Clone AC145
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简单介绍
APC - anti human CD123 - Clone AC145
APC - anti human CD123 - Clone AC145
的详细介绍
APC
- anti Human
CD123 - AC145
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AC145
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IgG2a
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FCM
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APC
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD123, clone AC145, is a mAb intended for the identification of DCs. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antibody reacts with the CD123 antigen, the α chain of the IL-3 receptor. This 60-70 kDa transmembrane protein binds to IL-3 with low affinity by itself, and when associated with CD131 (common β chain) binds IL-3 with high affinity. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes. At the level of the hematopoietic system IL-3R alpha expression was described on bone marrow CD34+ cells (including primitive multipotential and committed progenitors), granulocytes, monocytes/macrophages, megakaryocytes and B-lymphocytes. Although the IL-3R alpha is expressed on the large majority of progenitor cells, it does not seem to be expressed on the stem cell fraction.
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IL-3R, CDw123, Interleukin-3 receptor subunit alpha,
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3563
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41 KDa
