CF-Blue™ - anti human CD16 - Clone 3G8
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产品名称: CF-Blue™ - anti human CD16 - Clone 3G8
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CF-Blue™ - anti human CD16 - Clone 3G8
CF-Blue™ - anti human CD16 - Clone 3G8
的详细介绍
CF-Blue
- anti Human
CD16 - 3G8
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3G8
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IgG1
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FCM
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CF-Blue
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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Human polymorphonuclear leukocytes
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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Store in the dark at 2-8 °C
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This antibody reacts with the CD16-antigen. CD16 exists as two distinct isoforms, FcγRIIIA and FcγRIIIB. In humans, FcγRIIIA is expressed as a polypeptide-anchored form on monocytes, macrophages, and lymphocytes such as NK cells. T and B cells do not express this Fc receptor. FcγRIIIB is also detected on neutrophils as a GPI-anchored form. Expression of CD16 on lymphocytes and monocytes is similar in non-human primates. Binding of IgG leads to activation of signal transduction pathways, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release, and antigen presentation.
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FCRIII, Fc-gamma receptor IIIb, CD16, FCG3, FCGR3, IGFR10
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50-65 kDa
