APC - anti human CD49c - Clone VJ1/6
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产品名称: APC - anti human CD49c - Clone VJ1/6
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简单介绍
APC - anti human CD49c - Clone VJ1/6
APC - anti human CD49c - Clone VJ1/6
的详细介绍
APC
- anti Human
CD49c - VJ1/6
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VJ1/6
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IgG1
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FCM
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APC
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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Integrin alpha 3
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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This antibody reacts with the CD49c-antigen (VLA-3 alpha-chain or Integrin alpha-3/beta-1) a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. The monoclonal antibody VJ1/6 reacts with ? 3 integrin, a transmembrane glycoprotein which non-covalently associates with integrin ? 1 (CD29) to form the ?3b1 (CD49c/CD29,VLA-3) complex which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c is expressed mostly on endothelial and epithelial cells (basal epidermal layers). It is not expressed on platelets and is expressed weakly on peripheral blood leukocytes. The CD49c/CD29 complex serves as an adhesive receptor for kalinin or epiligrin. This interaction may be important for thymocyte interaction with thymic epithelium. This antibody is suitable for immunohistochemical staining on acetone-fixed frozen tissue sections
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Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 subunit alpha, MSK18, VCA-2; VL3A; VLA3a
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150 kDa
