PURE - anti human CD49d - Clone ALC1/1
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产品名称: PURE - anti human CD49d - Clone ALC1/1
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PURE - anti human CD49d - Clone ALC1/1
PURE - anti human CD49d - Clone ALC1/1
的详细介绍
PURE
- anti Human
CD49d - ALC1/1
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ALC1/1
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IgG1
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FCM
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PURE
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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Tissue / cell preparation (JM leukemia line).
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD49b, clone ALC1/1 is a mAb primarily expressed on T and B lymphocytes and weakly expressed on monocytes. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antibody reacts with the CD49d antigen, which recognizes the 150-kilodalton (kd) α-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and ? subunits and is involved in cell–cell and cell–extracellular matrix interactions. The ?-chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein. The CD29 antigen, also known as the ?-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ? integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.
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Alpha-4 integrin chain; VLA-4 alpha chain, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha
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3676
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150 kDa
