FITC - anti human CD55 - Clone JS11
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产品名称: FITC - anti human CD55 - Clone JS11
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FITC - anti human CD55 - Clone JS11
FITC - anti human CD55 - Clone JS11
的详细介绍
FITC
- anti Human
CD55 - JS11
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JS11
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IgG1
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FCM
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FITC
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Please refer to the Certificate of Analysis for the lot-specific concentration.
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The immunogen was the full length version of the protein
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Human
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD55, clone JS11 is a mAb valid for identification of DAF protein expressed on HCs including erythrocytes and many non-hematopoietic cells. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antibody reacts with the CD55-antigen (also known as DAF protein), a 41,4 kD glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein also known as decay-accelerating factor. It is expressed on hematopoietic cells including erythrocytes and many non-hematopoietic cells. This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of DAF with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade . CD55 has been reported to reduce the efficiency of NK cell lysis and induce signal transduction in T cells. CD55 has also been shown to interact with CD97 and bind to Coxsackie and Echovirus.
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Decay accelerating factor, DAF, CR
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1604
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60-70 kDa
