TEN1 Human

TEN1 telomerase capping complex subunit homolog (S. cerevisiae), C17orf106, CST complex subunit TEN1, Protein telomeric pathways with STN1 homolog, Telomere length regulation protein TEN1 homolog, TEN1.

TEN1 is part of a complex that binds to single-stranded DNA and is necessary in order to protect telomeres from DNA degradation (CST complex). The CST complex binds single-stranded DNA with high affinity in a sequence-independent mode, while isolated subunits bind DNA with low affinity by themselves. Further to telomere protection, the CST complex has most likely a more general part in DNA metabolism at non-telomeric sites.  

TEN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 146 amino acids (1-123) and having a molecular mass of 16.2kDa. TEN1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Escherichia Coli.

Sterile Filtered clear solution.

The TEN1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.15M NaCl, 10% glycerol and 1mM DTT.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Greater than 90% as determined by SDS-PAGE.

MGSSHHHHHH SSGLVPRGSH MGSMMLPKPG TYYLPWEVSA GQVPDGSTLR TFGRLCLYDM IQSRVTLMAQ HGSDQHQVLV CTKLVEPFHA QVGSLYIVLG ELQHQQDRGS VVKARVLTCV EGMNLPLLEQ AIREQRLYKQ ERGGSQ.

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