BMX Non-Receptor Tyrosine Kinase (BMX) Antibody
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产品名称: BMX Non-Receptor Tyrosine Kinase (BMX) Antibody
产品型号: abx015779
产品展商: 其他品牌
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简单介绍
BMX Non-Receptor Tyrosine Kinase (BMX) Antibody
BMX Non-Receptor Tyrosine Kinase (BMX) Antibody
的详细介绍
BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2.The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain.Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC.BMX kinase is expressed in fetal and ***** tissues, with the highest expression in heart, testis, small intestine and colon.It is undetectable in spleen, brain, kidney, and pancreas.Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia.The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.
| Target |
BMX |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human BMX expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
78 kDa |
| Swiss Prot |
P51813
|
| GeneID |
660
|
| Gene Symbol |
BMX |
| OMIM |
300101
|
| HGNC |
1079 |
| Ensembl |
ENSG00000102010 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
