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产品名称: c-Myc Antibody (FITC)
产品型号: abx139769
产品展商: 其他品牌
产品文档: 无相关文档
简单介绍
c-Myc Antibody (FITC)
的详细介绍
c-Myc Antibody is a Mouse Monoclonal against c-Myc.
| Target |
c-Myc |
| Reactivity |
General (All species) |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
WB, IHC, FCM, IP |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of Human c-Myc. |
| Isotype |
IgG1 |
| Conjugation |
FITC |
| Specificity |
The antibody may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells. |
| Storage |
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| GeneID |
4609
|
| Buffer |
PBS with 15 mM sodium azide, approx. pH 7.4. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-12 working days. |
| Note |
This product is for research use only. |
