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C17ORF53 Antibody

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产品名称: C17ORF53 Antibody
产品型号: abx015783
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简单介绍

C17ORF53 Antibody


C17ORF53 Antibody  的详细介绍
C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17.Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes.Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth.Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Target C17ORF53
Reactivity Human
Host Mouse
Clonality Monoclonal
Tested Applications ELISA, WB, FCM
Recommended dilutions ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. coli.
Purification Unpurified Ascites.
Isotype IgG2b
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight 69.8 kDa
Swiss Prot Q8N3J3
GeneID 78995
Gene Symbol C17orf53
HGNC 28460
Ensembl ENSG00000125319
Buffer Ascitic fluid containing 0.03% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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