Caspase 3 active Antibody
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产品名称: Caspase 3 active Antibody
产品型号: abx200557
产品展商: 其他品牌
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简单介绍
Caspase 3 active Antibody
的详细介绍
Caspase 3 active Antibody is a Rabbit Polyclonal against Caspase 3 active. Caspases are a family of cytosolic aspartate specific cysteine proteases involved in apoptosis and inflammation. Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a key protease that is activated during the early stages of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins during apoptosis, such as ply (APD-ribose) polymerase (PARP). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which is derived from the 32 kDa proenzyme and associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9).
| Target |
Caspase 3 active |
| Reactivity |
Human |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
WB: 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Synthetic peptide (KLH-conjugated) corresponding to amino terminal residues adjacent to Asp175 of human caspase-3. |
| Purity |
> 90% |
| Conjugation |
Unconjugated |
| Specificity |
The antibody preferentially recognizes the p17 fragment of the active Caspase-3, and Cleaved Caspase-3 (Asp175). |
| Storage |
Aliquoted and store in the dark at - 20 °C. Avoidrepeated freeze/thaw cycles. |
| Molecular Weight |
17 kDa |
| Swiss Prot |
P42574
|
| GeneID |
836
|
| Concentration |
3 mg/ml |
| Buffer |
20 mM PBS, 150 mM CINa, pH 7.2, 0.09% sodium azide. Does not contain BSA. |
| Availability |
Shipped within 3-5 working days. |
| Note |
This product is for research use only. |
