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CD43 Antibody (FITC)

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产品名称: CD43 Antibody (FITC)
产品型号: abx200285
产品展商: 其他品牌
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简单介绍

CD43 Antibody (FITC)


CD43 Antibody (FITC)  的详细介绍
CD43, the glycoprotein leukosialin (95-115kDa MW) antigen present on all T lymphocytes and on granulocytes, monocytes and platelets in peripheral blood. The antigen is also expressed cytoplasmically by macrophages. It is also present on all immature hematopoietic cells in the bone marrow. CD43 may be involved in the regulation of B, T and NK cell function.

Target CD43
Reactivity Human
Host Mouse
Clonality Monoclonal
Tested Applications FCM
Recommended dilutions FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Native purified from myeloblastic KG1 Cells.
Purification Affinity Chromatography
Form Liquid
Isotype IgG1
Conjugation FITC
Specificity CD43 is a large single chain of type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. Due to variable glycosylation and sialylation, two isoforms of CD43 have been identified. The 115 kD glycoform of CD43 is expressed on most hematopietic cells including T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells. It is not present on resting B cells and erythrocytes. While the 130 kD glycoform is thought to be activation-associated form primarily expressed on myeloid cells, pre-B cells, and activated T cells. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesion and anti-adhesion, as well as costimulation of T cell activation and survival, and induction of apoptosis of T cells and hematopoietic progenitors.
Storage Store in the dark at 2-8 °C.
Molecular Weight 95-115kDa
Swiss Prot P16150
GeneID 6693
Buffer The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
UNSPSC Code 12352203
Availability Shipped within 3-5 working days.
Note This product is for research use only.
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