CD62 Antigen-Like Family Member L (CD62L) Antibody
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产品名称: CD62 Antigen-Like Family Member L (CD62L) Antibody
产品型号: abx200420
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简单介绍
CD62 Antigen-Like Family Member L (CD62L) Antibody
CD62 Antigen-Like Family Member L (CD62L) Antibody
的详细介绍
This antibody recognizes CD62L, known as L-selectin, a 76 kDa molecule which is a member of the selectin family of adhesion receptors. These function in leucocyte binding to activated endothelium and in lymphocyte homing to high endothelial venules. The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium.
| Target |
CD62L |
| Reactivity |
Human |
| Host |
Mouse |
| Tested Applications |
FCM |
| Recommended dilutions |
FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Tissue / cell preparation: Peripheral blood leukocytes. |
| Purification |
Affinity Chromatography |
| Form |
Liquid |
| Isotype |
IgG2a |
| Conjugation |
Unconjugated |
| Specificity |
This antibody recognizes CD62L, known as L-selectin, a 76 kDa molecule which is a member of the selectin family of adhesion receptors. These function in leucocyte binding to activated endothelium and in lymphocyte homing to high endothelial venules. The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium. |
| Storage |
Store in the dark at 2-8 °C. |
| Molecular Weight |
76 kDa |
| Swiss Prot |
P14151
|
| GeneID |
6402
|
| Buffer |
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 2-3 weeks. |
| Note |
This product is for research use only. |
