Product Name
microphthalmia-associated transcription factor (MITF), Polyclonal Antibody
Full Product Name
Rabbit anti-human microphthalmia-associated transcription factor polyclonal Antibody
Product Synonym Names
microphthalmia-associated transcription factor; MITF; MI; WS2A; bHLHe32
Product Gene Name
anti-MITF antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11002 / sc-10999 / sc-25386
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MITF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MITF antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MITF. It may not necessarily be applicable to this product.
NCBI Accession #
BAA95209.1
[Other Products]
UniProt Secondary Accession #
Q14841; Q9P2V0; Q9P2V1; Q9P2V2; Q9P2Y8; B4DJL2; D3K197; E9PFN0[Other Products]
UniProt Related Accession #
O75030[Other Products]
Molecular Weight
52,527 Da[Similar Products]
NCBI Official Full Name
microphthalmia-associated transcription factor, partial
NCBI Official Synonym Full Names
microphthalmia-associated transcription factor
NCBI Official Symbol
MITF [Similar Products]
NCBI Official Synonym Symbols
MI; WS2; CMM8; WS2A; bHLHe32
[Similar Products]
NCBI Protein Information
microphthalmia-associated transcription factor; class E basic helix-loop-helix protein 32
UniProt Protein Name
Microphthalmia-associated transcription factor
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 32; bHLHe32
Protein Family
Microphthalmia-associated transcription factor
UniProt Gene Name
MITF [Similar Products]
UniProt Synonym Gene Names
BHLHE32; bHLHe32 [Similar Products]
UniProt Entry Name
MITF_HUMAN
NCBI Summary for MITF
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for MITF
MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described.
Protein type: Oncoprotein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 3p14.2-p14.1
Cellular Component: protein complex; nucleus
Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin binding
Biological Process: transcription from RNA polymerase II promoter; camera-type eye development; cell fate commitment; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; melanocyte differentiation; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; negative regulation of transcription from RNA polymerase II promoter; bone remodeling; regulation of cell proliferation
Disease: Albinism, Ocular, With Sensorineural Deafness; Waardenburg Syndrome, Type 2a; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome
Research Articles on MITF
1. Both MITF-1 and SOX10 can be used to differentiate melanoma in situ from actinic keratosis with melanocytic hyperplasia
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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