Full Product Name
KCNE2 Polyclonal Antibody
Product Synonym Names
ATFB4; cardiac voltage gated potassium channel accessory subunit 2; Kcne2; KCNE2_HUMAN; LQT5; LQT6; minimum potassium ion channel related peptide 1; Minimum potassium ion channel-related peptide 1; minK related peptide 1; MinK-related peptide 1; MIRP1; Potassium channel subunit beta MiRP1; potassium channel subunit; MiRP1; potassium voltage gated channel subfamily E member 2; potassium voltage gated channel; Isk related family; member 2; Potassium voltage-gated channel subfamily E member 2; voltage-gated K+ channel subunit MIRP1
Product Gene Name
anti-KCNE2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purification
Immunogen
A synthetic peptide of human KCNE2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-KCNE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KCNE2 antibody
Western Blot (WB)
Application Notes for anti-KCNE2 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-KCNE2 antibody
Western blot analysis of extracts of various cells, using KCNE2 antibody.
NCBI/Uniprot data below describe general gene information for KCNE2. It may not necessarily be applicable to this product.
UniProt Secondary Accession #
Q52LJ5; A5H1P3; D3DSF8[Other Products]
UniProt Related Accession #
Q9Y6J6[Other Products]
NCBI Official Full Name
KCNE2, partial
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily E regulatory subunit 2
NCBI Official Symbol
KCNE2 [Similar Products]
NCBI Official Synonym Symbols
LQT5; LQT6; ATFB4; MIRP1
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily E member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 2
UniProt Synonym Protein Names
MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNE2 [Similar Products]
UniProt Entry Name
KCNE2_HUMAN
NCBI Summary for KCNE2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE2
KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: cell surface; lysosome; plasma membrane; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; inward rectifier potassium channel activity; potassium channel regulator activity; protein binding
Biological Process: potassium ion import
Disease: Atrial Fibrillation, Familial, 4; Long Qt Syndrome 6
Research Articles on KCNE2
1. The identification of Filamin C as a novel KCNE2 ligand not only enhances current understanding of ion channel function and regulation, but also provides valuable information about possible pathways likely to be involved in long-QT syndrome pathogenesis
Precautions
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