Product Synonym Names
ATFB4; LQT5; LQT6; MIRP1
Product Gene Name
anti-KCNE2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y6J6
Purity/Purification
Affinity purification
Immunogen
A synthetic peptide of human KCNE2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-KCNE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNE2 antibody
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.
Applications Tested/Suitable for anti-KCNE2 antibody
Western Blot (WB)
Application Notes for anti-KCNE2 antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for KCNE2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_751951.1
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NCBI GenBank Nucleotide #
NM_172201.1
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UniProt Primary Accession #
Q9Y6J6
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UniProt Secondary Accession #
Q52LJ5; A5H1P3; D3DSF8[Other Products]
UniProt Related Accession #
Q9Y6J6[Other Products]
NCBI Official Full Name
potassium voltage-gated channel subfamily E member 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily E regulatory subunit 2
NCBI Official Symbol
KCNE2 [Similar Products]
NCBI Official Synonym Symbols
LQT5; LQT6; ATFB4; MIRP1
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily E member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 2
UniProt Synonym Protein Names
MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNE2 [Similar Products]
NCBI Summary for KCNE2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE2
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505).
Research Articles on KCNE2
1. On the basis of clinical phenotype, the high allelic frequencies of LQT6 mutations in the Exome Aggregation Consortium database, and absence of previous documentation of genotype-phenotype segregation, our findings suggest that many KCNE2 variants, and perhaps all, have been erroneously designated as LQTS-causative mutations. Instead, KCNE2 variants may confer proarrhythmic susceptibility when provoked by additional envir
Precautions
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