Product Name
KCNH1, cDNA Clone
Full Product Name
KCNH1 cDNA Clone
Product Gene Name
KCNH1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaccatgg ctgggggcag gaggggacta gtggcccctc aaaacacgtt tctggagaat attgttcggc ggtccaatga tactaatttt gtgttgggga atgctcagat agtggactgg cctattgtgt acagcaatga tggattttgc aagctgtctg gctatcacag ggcagaagtg atgcaaaaaa gcagcacctg cagttttatg tatggggagc tgactgataa agacacgatt gaaaaagtgc ggcaaacatt tgagaactat gagatgaatt cctttgaaat tctgatgtac aagaagaaca ggacacctgt gtggttcttt gtgaaaattg ctccaattcg aaacgaacag gataaagtgg ttttatttct ttgcactttc agtgacataa cagctttcaa acagccaatt gaggatgatt catgtaaagg ctgggggaag tttgctcggc tgacaagagc actgacaagc agcaggggtg tcctgcagca gctggctcca agcgtgcaaa aaggcgagaa tgtccacaag cactcccgcc tggcagaggt cctacagctg ggctcagaca tccttcccca gtacaagcaa gaggcaccaa agactccccc tcacatcatc ttacattatt gtgtttttaa gaccacgtgg gattggatca tcttgatctt gaccttctat acagccatct tggtccctta taatgtctcc ttcaaaacca ggcagaataa tgtggcctgg ctggttgttg atagcatcgt ggatgttatc tttttggtgg acattgtgct caattttcat accacctttg ttggaccagc aggggaggtg atttctgacc ccaaacttat ccgcatgaac tacctgaaga cgtggtttgt gattgacctt ctgtcctgtt tgccatatga tgtcatcaac gcttttgaga acgtggatga gggcatcagc agcctgttca gctctctaaa agttgtccgg ctgctccgtc ttgggcgagt ggcccgtaag ctggaccact acattgaata tggagctgct gtgctggtcc tgctggtgtg tgtgtttggg ctggctgcac actggatggc ctgcatctgg tacagcattg gggactatga gatctttgac gaggacacca agacaatccg caacaacagc tggctgtacc aactagcgat ggacattggc accccttacc agtttaatgg gtctggctca gggaagtggg aaggtggtcc cagcaagaat tctgtctaca tctcctcgtt gtatttcaca atgaccagcc tcaccagtgt gggctttggg aacatcgccc catccacaga cattgagaag atctttgcag tggccatcat gatgattggc tcacttctct atgccaccat cttcgggaat gtgacgacta ttttccaaca gatgtatgcc aacaccaaca gataccatga gatgctcaac agtgttcggg acttcctgaa gctctaccag gtgccaaaag gattgagtga gcgagtaatg gattatattg tgtccacttg gtccatgtcc agaggcattg acacagagaa ggtcctgcag atctgcccca aggacatgag agccgacatc tgcgtgcacc tgaaccgcaa ggtgttcaag gagcacccgg ccttccggct ggccagtgat ggctgcctcc gggcactggc catggagttc cagacggtgc actgtgcccc aggggacctc atctaccatg caggagagag cgttgacagc ctctgctttg tggtttctgg ctccctggag gtgatccaag atgatgaggt ggtggccatt ctaggaaaag gagacgtgtt tggagatgtg ttctggaagg aagccaccct tgcccagtcc tgtgccaatg ttagggcctt gacctactgt gatctgcatg tgatcaagcg ggatgccctg cagaaagtgc tggaattcta cacggccttc tcccattcct tctcccggaa cctgattctg acgtacaact tgaggaagag gattgtgttc cggaagatca gcgacgtgaa acgtgaagag gaagaacgca tgaaacgaaa gaatgaggcc cccctgatct tgcccccgga ccaccctgtc cggcgcctct tccagagatt ccgacagcag aaagaggcca ggctggcagc tgagagaggg ggccgggacc tggatgacct agatgtggag aagggcaatg tccttacaga gcatgcctcc gccaaccaca gcctcgtgaa ggccagcgtg gtcaccgtgc gtgagagtcc tgccacgccc gtatccttcc aggcagcctc cacctccggg gtgccagacc acgcaaagct acaggcgcca gggtccgagt gcctgggccc caaggggggc gggggcgatt gtgccaagcg caaaagctgg gcccgcttca aagatgcttg cgggaagagt gaggactgga acaaggtgtc caaggctgag tcgatggaga cacttcccga gaggacaaaa gcgtcaggcg aggccacact gaagaagaca gactcgtgtg acagtggcat caccaagagc gacttgcgcc tggacaacgt gggtgaggcc aggagtcccc aggatcggag tcccatcctg gcagaggtca agcattcgtt ctaccccatc cctgagcaga cgctgcaggc cacagtcctg gaggtgaggc acgagctgaa ggaggacatc aaggccttaa acgccaaaat gaccaatatt gagaaacagc tctctgagat actcaggata ttaacttcca gaagatcctc tcagtctcct caggagttgt ttgaaatatc gaggccacag tccccagaat cagagagaga catttttgga gccagctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KCNH1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KCNH1. It may not necessarily be applicable to this product.
NCBI Accession #
BC113709
[Other Products]
UniProt Secondary Accession #
O76035; Q14CL3; B1AQ26[Other Products]
UniProt Related Accession #
O95259[Other Products]
Molecular Weight
108,597 Da
NCBI Official Full Name
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 1, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 1
NCBI Official Symbol
KCNH1 [Similar Products]
NCBI Official Synonym Symbols
EAG; EAG1; ZLS1; TMBTS; h-eag; hEAG1; Kv10.1
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily H member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 1
UniProt Synonym Protein Names
Ether-a-go-go potassium channel 1; EAG channel 1; h-eag; hEAG1; Voltage-gated potassium channel subunit Kv10.1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNH1 [Similar Products]
UniProt Synonym Gene Names
EAG; EAG1; EAG channel 1; h-eag; hEAG1 [Similar Products]
UniProt Entry Name
KCNH1_HUMAN
NCBI Summary for KCNH1
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNH1
Kv10.1: Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: early endosome membrane; integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function: cyclic nucleotide binding; delayed rectifier potassium channel activity; protein binding
Biological Process: myoblast fusion; potassium ion transport; regulation of cell proliferation; regulation of membrane potential
Disease: Temple-baraitser Syndrome; Zimmermann-laband Syndrome 1
Research Articles on KCNH1
1. Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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