Full Product Name
KCNH2 Antibody
Product Synonym Names
ERG1; HERG; LQT2; SQT1; HERG1; Kv11.1
Product Gene Name
anti-KCNH2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q12809
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
A synthetic peptide of human KCNH2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-KCNH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNH2 antibody
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
Product Categories/Family for anti-KCNH2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-KCNH2 antibody
Western Blot (WB)
Application Notes for anti-KCNH2 antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-KCNH2 antibody
Western blot analysis of extracts of Mouse brain tissue lysate, using KCNH2antibody.
NCBI/Uniprot data below describe general gene information for KCNH2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000229.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000238.3
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UniProt Primary Accession #
Q12809
[Other Products]
UniProt Secondary Accession #
O75418; O75680; Q708S9; Q9BT72; Q9BUT7; Q9H3P0; A5H1P7; C4PFH9; D3DX04[Other Products]
UniProt Related Accession #
Q12809[Other Products]
NCBI Official Full Name
potassium voltage-gated channel subfamily H member 2 isoform a
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 2
NCBI Official Symbol
KCNH2 [Similar Products]
NCBI Official Synonym Symbols
ERG1; HERG; LQT2; SQT1; ERG-1; H-ERG; HERG1; Kv11.1
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily H member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 2
UniProt Synonym Protein Names
Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNH2 [Similar Products]
UniProt Synonym Gene Names
ERG; ERG1; HERG; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1 [Similar Products]
NCBI Summary for KCNH2
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNH2
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).
Research Articles on KCNH2
1. Data show that ether-a-go-go-related 1 (hERG1) ion channel expression knockdown elicited a reversion of the epithelial to the mesenchymal state (EMT) profile in colorectal cancer HCT116 cells with a reacquisition of the epithelial-like profile.
Precautions
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Disclaimer
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