CYB5R3, Antibody

B5R; cytochrome b5 reductase; cytochrome b5 reductase 3; DIA1; diaphorase; diaphorase (NADH) (cytochrome b-5 reductase); diaphorase-1; EC 1.6.2.2; NADH-cytochrome b5 reductase; NB5R3; NCB5R

For Research Use Only. Not for use in diagnostic procedures.

CYB5R3 Antibody detects endogenous levels of total CYB5R3

Immunogen affinity purified

In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C. Stable for 12 months from date of receipt.

Small volumes of anti-CYB5R3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:1000
IHC: 1:50-1:200

Western blot analysis of extracts from COLO cells, HUVEC cells, HT-29 cells, K562 cells and HepG2 cells, using CYB5R3 antibody.

34 KD

cytochrome b5 reductase 3

NADH-cytochrome b5 reductase 3

NADH-cytochrome b5 reductase 3

DIA1; B5R; Cytochrome b5 reductase  [Similar Products]

This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]

Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

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